After 3 and 5 weeks of treatment, the dose was increased by increments of 75 mg/day up to 225 mg/day venlafaxine XR and 450 mg/day trazodone OAD in nonresponding patients.
Generic: 50 mg, 100 mg, 150 mg, 300 mg. Pharmacology Mechanism of Action. Inhibits reuptake of serotonin, causes adrenoreceptor subsensitivity, acts as a 5HT 2a receptor antagonist and induces significant changes in 5-HT presynaptic receptor adrenoreceptors. Trazodone also significantly blocks histamine (H 1) and alpha1-adrenergic receptors.Variance in excretion times are often a result of variables such as: the individual taking Trazodone, dosage taken, duration of administration, and co-ingestion of other drugs. Individual factors; Two people may simultaneously administer a single 50 mg dose of Trazodone, yet one person may excrete the drug at a faster rate than the other.
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